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蔡云飞，男，重庆璧山人，理学博士。2017年10月以“百人计划”加入重庆大学化学化工学院，任研究员、博士生导师。2009年本科毕业于四川大学化学学院，随后师从冯小明教授留校继续学习，并于2014年7月获得博士学位。同年获得德国洪堡学者奖学金，于2014年至2016年在德国亚琛工业大学从事博士后研究，2016年10月至2017年10月在沙特阿拉伯阿卜杜拉国王科技大学（KAUST）继续从事博士后研究，合作导师均为Magnus Rueping教授。主要从事有机合成方法学、药物化学、材料化学等方面的研究。主持国家自然科学基金青年和面上项目、重庆市科委项目、重庆市人社局留创项目、重庆大学科研启动基金、中央高校经费等。以通讯作者或第一作者在 Nat. Commun.、JACS、 Angew. Chem. Int. Ed.、 ACS Catal.、Green Chem.、Org. Lett.等期刊上发表论文40余篇，其中多篇被Angew. Chem. Int. Ed.、Synfacts、Synform等作亮点评论，论文被引用1800余次，h-因子27。

 

联系方式

电话：15928708564                 

E-mail: yf.cai@cqu.edu.cn

通信地址：重庆市沙坪坝区大学城南路55号 重庆大学虎溪校区理科楼化学化工学院LC727（邮编：401331）

研究方向

主要研究方向：有机合成新方法的开发及其在具有生理活性或药用价值分子合成中的应用。

主要研究内容：不对称接力/协同催化新反应、半导体非均相光催化有机转化。欢迎有意向读硕、读博的同学报考。

代表性论文、专著和专利

Independent Work (after 2017)

  1. Atomically precise single-atom cobalt photocatalyst for enhanced decarboxylative cross-couplings

    Qian Yang, Mengting Wu, Wanlin Wang, Wentao Wang, Han Wang, Yurong Tang*, Magnus Rueping*, Yunfei Cai*, Chem. Sci. 2025, 16, 19154–19163.

  2. Photoredox/Brønsted Acid-Catalyzed Asymmetric Difluoroalkylation/Rearrangement of Alkenylfurans

    Kunlong Yang, Menghan Qin, Yurong Tang*, Yunfei Cai*, Org. Lett. 2025, 27, 14328–14333.

  3. Photoinduced Ligand-to-Metal Charge Transfer Enables Iron-Catalyzed Site-Selective Oxime Ether Construction at C(sp3)-H Bonds of Silanes

    Zhijun Hao, Xiushan Liu, Yunfei Cai*, Huifeng Yue*, Org. Lett. 2025, 27, 13786–13791.

  4. Efficient syntheses of 2-amino-4H-pyrans via gold-catalyzed cyclization of diester-tethered ynamides

    Jianfeng Zheng*, Dong Xiong, Yongqi Ye, Luhao Tang, Jiajin Yang, Zeyu Yanga, Yunfei Cai*, Chem. Commun. 2025, 61, 16858–16861.

  5. Enantioselective Synthesis of N‑Cyclopentenyl Sulfoximines via the Catalytic Asymmetric Aza-Piancatelli Reaction

    Hongji Tao, Mengting Wu, Yurong Tang, Pengfei Zhou*, Yunfei Cai*, Org. Lett. 2025, 27, 10065–10069.

  6. Multicomponent Modular Synthesis of Chiral Bicyclic Bridged Compounds via an Alkenylfuran-Based Acylation/Rearrangement/Cyclization Sequence

    Yu Tian, Hongji Tao, Kunlong Yang, Yurong Tang*, Yunfei Cai*, Org. Lett. 2025, 27, 1181–1185.

  7. Stereoselective construction of 5-6-5 aza-tricyclic scaffolds via catalytic asymmetric aza-Piancatelli/Diels-Alder reactions

    Lishu Wang, Han Wang, Xukun Nie, Jun Li*, Yurong Tang, Yunfei Cai*, Chem. Commun. 2025, 61, 8395–8398.

  8. Enantioselective Synthesis of N‑Substituted Indoles with α,β-Stereocenters via Sequential Aza-Piancatelli/Cyclization Reactions

    Kaijun Xie, Xukun Nie, Pengfei Zhou*, Yurong Tang, Yunfei Cai*, Org. Lett. 2025, 27, 4806−4810.

  9. Stereoselective Access to Spiro-isoindolinone Scaffolds via Catalytic Asymmetric aza-Piancatelli Rearrangement

    Ling Yu, Yurong Tang*, Xukun Nie, Yunfei Cai*, Org. Lett. 2024, 26, 7667–7671.

  10. Asymmetric Construction of Functionalized Cyclopenta[b]pyrrolines via Cascade Aza-Piancatelli/Hydroamination Reactions

    Xukun Nie, Sishi Zhong, Jiaming Zou, Yurong Tang*, Yong Xia*, Yunfei Cai*, Org. Lett. 2024, 26, 6766−6770.

  11. Poly(Heptazine Imide) Ligand Exchange Enables Remarkable Low Catalyst Loadings in Heterogeneous Metallaphotocatalysis

       Liuzhuang Xing, Qian Yang, Chen Zhu, Yilian Bai, Yurong Tang*, Magnus Rueping*, Yunfei Cai*, Nat. Commun. 2023, 14, 1501.

          (Featured by the Editor: Editors’ Highlights in Catalysis; Highlighted by Synfacts 2023, 19, 0594).

12.  Heterogeneous Metallaphotocatalytic C(sp2)−C(sp3) Cross-Coupling Reactions with Integrated Bipyridyl-Ni(II)-Carbon Nitride

        Xiao Dan, Qian Yang, Liuzhuang Xing, Yurong Tang,* Wentao Wang*, Yunfei Cai*, Org. Lett. 2023, 25, 4124–4129 (front cover).

13.    Copper-doped carbon nitride as a practical heterogeneous metallaphotocatalyst for aerobic oxidative cross-coupling of tertiary amines with  terminal alkynes

        Yilian Bai, Qian Yang, Yurong Tang,* Xiao Dan, Wentao Wang,* Yunfei Cai*, Green Chem. 2023, 25, 4446–4452.

14.    Cu(I)/Chiral Vanadium Complex Cooperatively Catalyzed Asymmetric Sulfonation/Rearrangement of Alkenylfurans

        Hongxiang Li, Qian Yang, Lei Xu, Jie Wei, Yurong Tang*, and Yunfei Cai*, Org. Lett. 2022, 24, 8202–8207.

15.    Asymmetric Ketoalkylation/Rearrangement of Alkyenlfurans via Synergistic Photoredox/Brønsted Acid Catalysis

        Jie Wei, Yurong Tang*, Qian Yang, Hongxiang Li, Dongxian He*, and Yunfei Cai*, Org. Lett. 2022, 24, 7928–7933.

16.    Organocatalytic Asymmetric Synthesis of Bridged Tetrahydrobenzo[b]azepines/oxepines

        Jiaming Zou, Lei Xu, Yurong Tang*, Wentao Wang, and Yunfei Cai*, Org. Lett. 2022, 24, 7140–7144 (Highlighted by Synfacts 2023, 19, 0078).

17.    Retro-Aza-Piancatelli Rearrangement Triggered Cascade Reaction of Methyl Furylacrylates with Anilines to Access  Cyclopenta[b]pyrrolidinones 

       Lei Xu, Hongxiang Li, Liuzhuang Xing, Qian Yang, Yurong Tang, and Yunfei Cai*, J. Org. Chem. 2022, 87, 855–865.

18.    Recent Advances on Piancatelli Reactions and Related Cascade Processes

       Sishi Zhong, Lei Xu, and Yunfei Cai*, Synthesis 2022, 54, 589–599 (Invited Review).

19.   Construction of metal (Mn, Ce, Eu)-containing species in CN nanocomposites with photo-responsive oxidase-mimicking activity for multi-antioxidant discrimination

       Fan Du, Xiaojie Zhou, Yilian Bai, Qing Tang, Yunfei Cai*, and Yurong Tang*, New J. Chem. 2022, 46, 6670–6676.

20.   Catalytic Asymmetric Radical-Mediated Three-Component Piancatelli-Type Rearrangement of Furylalkenes

        Lei Xu, Sishi Zhong, Qian Yang, Jie Wei, Jiaming Zou, Hongxiang Li, and Yunfei Cai*, ACS Catal. 2021, 11, 10198–10207.

21.   Semi-heterogeneous photocatalytic fluoroalkylation-distal functionalization of unactivated alkenes with RFSO2Na under air atmosphere

        Yali He, Xiao Dan, Yurong Tang*, Qian Yang, Wentao Wang*, and Yunfei Cai*, Green Chem. 2021, 23, 9577–9582

22.    Remarkable Activity of Potassium-Modified Carbon Nitride for Heterogeneous Photocatalytic Decarboxylative

         Alkyl/Acyl Radical Addition and Reductive Dimerization of para-Quinone Methides

        Qian Yang, Guanglong Pan, Jie Wei, Wentao Wang, Yurong Tang*, and Yunfei Cai*, ACS Sustain. Chem. Eng. 2021, 9, 2367–2377.

23.    Heterogeneous Photocatalytic Cyanomethylarylation of Alkenes with Acetonitrile: Synthesis of Diverse Nitrogenous Heterocyclic Compound

        Guanglong Pan, Qian Yang, Wentao Wang, Yurong Tang*, and Yunfei Cai*, Beilstein J. Org. Chem. 2021, 17, 1171–1180.

24.   Ln(III)/Chiral Brønsted Acid Catalyzed Asymmetric Cascade Ring Opening/Aza-Piancatelli Rearrangement of D-A Cyclopropanes

        Lei Xu, Qian Yang, Shisi Zhong, Hongxiang Li, Yurong Tang,* and Yunfei Cai*, Org. Lett. 2020, 22, 9016–9021.

25.    A g-C3N4-based Heterogeneous Photocatalyst for Visible Light Mediated Aerobic Benzylic C-H Oxygenations.

        Pengxin Geng, Yurong Tang, Guanglong Pan, Wentao Wang, Jinchuan Hu*, and Yunfei Cai*, Green. Chem. 2019, 21, 6116–6122.

26.   Asymmetric Catalytic Halofunctionalization of α,β-Unsaturated Carbonyl Compounds

        Yunfei Cai, Xiaohua Liu, Pengfei Zhou, and Xiaoming Feng*, J. Org. Chem. 2019, 84, 1–13 (Invited Perspective).

27.   Heterogeneous Visible-Light Photoredox Catalysis with Graphitic Carbon Nitride for α-Aminoalkyl Radical Additions, Allylations, and Heteroarylations

        Yunfei Cai, Yurong Tang, Lulu Fan, Quntin Lefebvre, Hong Hou, Magnus Rueping*. ACS Catal. 2018, 8, 9471−9476.


Prior to CQU (before 2017)

28.    Catalytic AsymmetricPiancatelli Rearrangement: Brønsted Acid Catalyzed 4π Electrocyclization for the Synthesis 

        of Multisubstituted Cyclopentenones

         Yunfei Cai, Yurong Tang, Iuliana Atodiresei, and Magnus Rueping*, Angew. Chem. Int. Ed. 2016, 55, 14126–14130.

29.    Diastereoselectively Switchable Asymmetric Haloaminocyclization for the Synthesis of Cyclic Sulfamates

         Yunfei Cai, Pengfei Zhou, Xiaohua Liu, Jiannan Zhao, Lili Lin, and Xiaoming Feng*, Chem. Eur. J. 2015, 21, 6386–6389.

30.    Iron-Catalyzed Asymmetric Haloamination Reactions

         Yunfei Cai, Xiaohua Liu, Pengfei Zhou, Yulong Kuang, Lili Lin, and Xiaoming Feng*, Chem. Commun. 2013, 49, 8054–8056.

31.    Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles

         Yunfei Cai, Jun Li, Weiliang Chen, Mingsheng Xie, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, Org. Lett. 2012, 14, 2726–2729.

32.    Asymmetric Iodoamination of Chalcones and 4-Aryl-4-oxobutenoates Catalyzed by a Complex Based on Scandium(III) and a N,N′-Dioxide Ligand

         Yunfei Cai, Xiaohua Liu, Jun Li, Wentao Wang, Weiliang Chen, Lili Lin, and Xiaoming Feng*, Chem. Eur. J. 2011, 17, 14916–14921.

33.    Asymmetric Chloroamination Reaction of α,β-Unsaturated γ-Keto Esters and Chalcones

         Yunfei Cai, Xiaohua Liu, Jun Jiang, Weiliang Chen, Lili Lin, and Xiaoming Feng*, J. Am. Chem. Soc. 2011, 133, 5636–5639.

34.    Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-amino Ketone Derivatives

         Yunfei Cai, Xiaohua Liu, Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Lili Lin, and Xiaoming Feng*, Angew. Chem. Int. Ed. 2010, 49, 6160–6164.

35.   Highly enantioselective α-chlorination of cyclic β-ketoesters catalyzed by N,N’-Dioxide using NCS as the chlorine source

        Yunfei Cai, Wentao Wang, Ke Shen, Jun Wang, Xiaolei Hu, Lili Lin, Xiaohua Liu and Xiaoming Feng*, Chem. Commun. 2010, 46, 1250–1252.

36.    A Triple-channel Sensing Array for Protein Discrimination Based on Multi-photoresponsive g-C3N4 

         Yuanli Long, Shuang Liu, Yunfei Cai, Jiale Zhang, Xinfeng Zhang*, Yurong Tang*, Microchimica Acta 2020, 187, 449.

37.    Electrochemical and Scalable Dehydrogenative C(sp3)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

        Pavlo Nikolaienko, Marc Jentsch, Ajit P. Kale, Yunfei Cai, Magnus Rueping*, Chem. Eur. J. 2019, 25, 7177–7184.

38.    Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C−O and C−C Bond Activation

        Huifeng Yue, Lin Guo, Hsuan-Hung Liao, Yunfei Cai, Chen Zhu and Magnus Rueping*, Angew. Chem. Int. Ed. 2017, 56, 4282–4285.

39.    Catalytic Asymmetric Intra- and Intermolecular Haloetherification of Enones: An Efficient Approach to (−)-Centrolobine

        Pengfei Zhou, Yunfei Cai, Xia Zhong, Weiwei Luo, Tengfei Kang, Jun Li, Xiaohua Liu*, Lili Lin, and Xiaoming Feng*, ACS Catal. 2016, 6, 7778–7783.

40.    Asymmetric Synthesis of Spirocyclic Oxindole-Fused Tetrahydrothiophenes via N,N′-Dioxide–Nickel(II) Catalyzed Domino Reaction of 1,4-Dithiane-2,5-diol with 3-Alkenyloxindoles

        Pengfei Zhou, Yunfei Cai, Lili Lin, Xiangjin Lian, Yong Xia, Xiaohua Liu and Xiaoming Feng*, Adv. Synth. Catal. 2015, 357, 695–700.

41.    Catalytic asymmetric [3+2] cycloaddition of aromatic aldehydes with oxiranes by C–C bond cleavage of epoxides: highly efficient synthesis of chiral 1,3-dioxolanes

        Weiliang Chen, Lili Lin, Yunfei Cai, Yong Xia, Weidi Cao, Xiaohua Liu and Xiaoming Feng *, Chem. Commun. 2014, 50, 2161–2163.

42.    Catalytic Asymmetric [8+2] Cycloaddition: Synthesis of Cycloheptatriene-Fused Pyrrole Derivatives

        Mingsheng Xie, Xiaohua Liu, Xiaoxia Wu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Angew. Chem. Int. Ed. 2013, 52, 5604-5607.

43.    Highly Stereoselective Conjugate Addition and α-Alkynylation Reaction with Electron-Deficient Alkynes Catalyzed by Chiral Scandium(III) Complexes

        Zhen Wang, Zuliang Zhang, Qian Yao, Xiaohua Liu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Chem. Eur. J. 2013, 19, 8591–8596.

44.    Highly Enantioselective Fluorination of Unprotected 3‑Substituted Oxindoles: One-Step Synthesis of BMS 204352 (MaxiPost)

        Jun Li, Yunfei Cai, Weiliang Chen, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, J. Org. Chem. 2012, 77, 9148–9155.

45.    A Catalytic Asymmetric Ring-Expansion Reaction of Isatins and a-Alkyl-a-Diazoesters: Highly Efficient Synthesis of Functionalized 2-Quinolone Derivatives

        Wei Li, Xiaohua Liu, Xiaoyu Hao, Yunfei Cai, Lili Lin, and Xiaoming Feng*, Angew. Chem. Int. Ed. 2012, 51, 8644–8647.

46.    Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by a Chiral Bisguanidium Salt

        Xiao Xiao, Xiaohua Liu, Shunxi Dong, Yunfei Cai, Lili Lin, Xiaoming Feng*, Chem. Eur. J. 2012, 18, 15922–15926.

47.    Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition

        Jun Jiang, Yunfei Cai, Weiliang Chen, Lili Lin, Xiaohua Liu and Xiaoming Feng*, Chem. Commun. 2011, 47, 4016–4018.

48.    Enantioselective One-Pot Synthesis of 2-Amino-4-(indol-3-yl)-4H-Chromenes

        Weiliang Chen, Yunfei Cai, Xuan Fu, Xiaohua Liu, Lili Lin, and Xiaoming Feng*, Org. Lett. 2011, 13, 2011, 4910–4913.

49.    Highly Enantioselective Zinc-Catalyzed Friedel–Crafts Alkylation of Indoles with Ethyl Trifluoropyruvate

        Yonghai Hui, Weiliang Chen, Wentao Wang, Jun Jiang, Yunfei Cai, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Adv. Synth. Catal. 2011, 18, 3174-3178.

50.    Highly Enantioselective Conjugate Addition of Thioglycolate to Chalcones Catalyzed by Lanthanum: Low Catalyst Loading and Remarkable Chiral Amplification

        Yonghai Hui, Jun Jiang, Wentao Wang, Weiliang Chen, Yunfei Cai, Lili Lin, Xiaohua Liu, Xiaoming Feng*, Angew. Chem. Int. Ed. 2010, 49, 4290-4293.

51.    Chiral N,N'-Dioxide-Yb(III) Complexes Catalyzed Enantioselective Hydrophosphony- lation of Aldehydes

        Weiliang Chen, Yonghai Hui, Xin Zhou, Jun Jiang, Yunfei Cai, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Tetrahedron Lett. 2010, 51, 4175–4178.

52.    Facile and Efficient Enantioselective Strecker Reaction of Ketimines by Chiral Sodium Phosphate.

        Ke Shen, Xiaohua Liu, Yunfei Cai, Lili Lin, Xiaoming Feng*, Chem. Eur. J. 2009, 15, 6008–6014.

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