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王治永 博士/副教授硕士生导师,2009年毕业于复旦大学化学系有机化学专业,获理学博士学位;20098-2010年8月在美国纽约州立大学布法罗分校从事博士后研究;2010年11月进重庆大学化学化工学院工作。主持国家自然科学基金青年基金项目重庆市自然科学基金面上项目教育部留学回国人员启动基金重庆大学人才引进科研启动基金中央高校基本科研项目等。2020年入选爱思维尔中国高被引学者(化学)榜单

联系方式

E-mailzwang@cqu.edu.cnQQ: 23140666; 实验室理科楼LC721

研究方向

Ø 新型小分子荧光探针的设计、合成及应用:

1)生物体系内活性物种的检测和细胞成像;

2)等离子体活化水中ROS/RNS的特异性诊断;

Ø 功能分子导向的有机合成方法学研究;

Ø 药物导向的有机合成方法学;

代表性论文、专著和专利

[1] Chaofan Wang, Ling Fang*, Lingling Zhang, Ya Wang, Fang, Gao, Zhiyong Wang* Base-mediated unprecedented tandem cyclization reaction of nitrilimines and sulfur ylides: facile approaches to multifunctionalized pyrazolines. Org. Chem. Front. 2022, DOI10.1039/D2QO00232A.

[2] Lijie Zhang, Ling Fang*, Hao Huang, Chaofan Wang, Fang Gao, Zhiyong Wang* Synthesis of Benzo[e][1,4]thiazepines by Base-Induced Formal [4+3] Annulation Reaction of Azaoquinone Methides and Pyridinium 1,4-Zwitterionic Thiolates J. Org. Chem. 2021, 86, 18156.

[3] Chaofan Wang, Ling Fang, Zhiyong Wang* Base-induced inverse-electron-demand aza-Diels-Alder reaction of azoalkenes and 1,3,5-triazinanes: Facile approaches to tetrahydro-1,2,4-triazines. Tetrahedron Lett. 2021, 79, 153303.

[4] Zhengqiang Wang, Xinchao Wang, Shengtao Zhang, Zhiyong Wang*, Fang Gao*, Hongru Li* Simple and prompt protonation of new dyes containing double conjugated imine bonds to strengthen the protection of copper in aggressive sulfuric acid solution, J. Mol. Liq. 2021, 341, 117402.

[5] Zhefeng Li*, Wending Hu, Zejun Li, Zhiyong Wang. Study on the Characteristics of Photovoltaic and Field Effect of Small Molecule Donors, IEEE Electr. Device L. 2020, 41, 1516-1519.

[6] Zejun Li, Wending Hu, Zhefeng Li*, Zhiyong Wang*. High performance n-type organic field-effect transistors based on halogenated derivatives of naphthalene tetracarboxylic diimides, Mat. Sci. Semicon. Proc. 2020, 120, 105273.

[7] Wei Luo, Wenpo Li, Jian Tan, Jie Liu, Bochuan Tan, Xiuli Zuo, Zhiyong Wang, Xin Zhang. A combined experimental and theoretical research of the inhibition property of 2-((6-chloropyridazin-3-yl)thio)-N,N-diethylacetamide as a novel and effective inhibitor for Cu in H2SO4 medium, J. Mol. Liq. 2020, 314, 113630.

[8] Haijun Huang;Yan Fu; Xiaojing Mu; Ziping Luo; Shengtao Zhang*; Zhiyong Wang*; Hongru Li*; Fang Gao*; Molecular self-assembly of novel amphiphilic topological hyperbranched polymers for super protection of copper in extremely aggressive acid solution, Appl. Surf. Sci. 2020, 529, 147076.

[9] Haijun Huang, Yan Fu, Fuhua Li, Zhenqiang Wang, Shengtao Zhang*, Xinchao Wang*, Zhiyong Wang*, Hongru Li*, Fang Gao* Orderly self-assembly of new ionic copolymers for efficiently protecting copper in aggressive sulfuric acid solution, Chem. Eng. J., 2020, 384, 123293.

[10] Wenhao Yin (本科生), Ling Fang, Zhiyong Wang (本科生), Fang Gao, Zhefeng Li*, Zhiyong Wang* Synthesis of Bicyclo[4.1.0]tetrahydropyridazines by a Sequential [4 + 2] and [1 + 2] Annulation Reaction of Azoalkenes and Crotonate-Derived Sulfur Ylides, Org. Lett. 2019, 21, 7361

[11] Zhiyong Wang (本科生), YanzhouYang, Fang Gao, Zhiyong Wang*, Qian Luo, Ling Fang* Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4+1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes. Org. Lett. 2018, 20, 934–937. (IF=6.579)

[12] Wuyan Long (本科生), Shuangqun Chen, Xiaohong Zhang (本科生), Ling Fang, Zhiyong Wang*.Diversity-oriented synthesis of 1,2,3,5-tetrahydrobenzo[e][1,2,4]oxadiazepines and 2,3-dihydro-1H-benzo[e][1,2,4] triazepines by base-induced [4 + 3] annulation reactions, Tetrahedron 2018, 74, 6155-6165.

[13] Ling Fang, Lijun Xue, Peng Yang, Xiaodan Li, Zhiyong Wang* A Facile Route to 4-Polyfluoroarylquinolin-2(1H)-ones and 4-Polyfluoroarylcoumarins via C-H Bond Activation. Chem. Lett. 2017, 46, 1223–1226.

[14] Xiaozhuan Qin, Ge Ding, Ziping Luo, Zhiyong Wang, Shengtao Zhang, Hongru Li,* Fang Gao* A mild acid-free one-pot reaction for synthesis of new phenanthridine dyes. Dyes Pigments 2016, 134, 613.

[15] Zhen Chen, Zhiyong Wang* An efficient route to diverse 2H-pyrano[3,2-c]quinolin- 5(6H)-ones via electrophilic cyclization reactions. Tetrahedron 2016, 72, 4288.

[16] Zhiyong Wang*, Liun Xue, Yiyi He, Ling Fang* Access to Functionalized 3H-Pyrrolo[2,3-c]quinolin-4(5H)-ones and  Thieno[2,3-c]quinolin-4(5H)-ones via Domino Reaction of 4-Alkynyl-3-bromo-quinolin-2(1H)-ones. J. Org. Chem. 2014, 79, 9628.

[17] Xianbo Wang, Liun Xue, Zhiyong Wang* A Copper-Catalyzed Three-Component Reaction of Triethoxysilanes, Sulfur Dioxide, and Hydrazines. Org. Lett. 2014, 16, 4056.

[18] Xianbo Wang, Zhiyong Wang* A tandem reaction of 2-alkynylbenzaldoximes with cyclic ethers co-catalyzed by silver(I) triflate and copper(II) acetate. Tetrahedron 2014, 70, 6728.

[19] Xianbo Wang, Zhiyong Wang* An approach to 1-phosphorylated isoquinolines through silver(I)-catalyzed tandem reaction involving C–N and C–P bond formation. Tetrahedron 2014, 70, 5720.

[20] Zhiyong Wang*, Xiaoxiao Xing, Liun Xue, Yan Xiong, Ling Fang* Iron(III) Chloride Catalyzed Formation of Aryl Hydrazides from Electron-Rich Arenes and Azodicarboxylates, Synthesis 2014, 757.

[21] Hongliang Liu, Zhiyong Wang*, Shouzhi Pu, Gang Liu* Synthesis of H-Pyrazolo[5,1-a]isoquinolines via Silver(I)-Catalyzed Tandem Reaction of N′-(2-Alkynylbenzylidene)hydrazides with Propargyl Amine Derivatives. Synthesis 2014, 600.

[22] Zhiyong Wang,* Xiaoxiao Xing, Lijun Xue, Fang Gao, Ling Fang* Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization. Org. Biomol. Chem. 2013, 11, 7334.

[23] Hongliang Liu, Gang Liu*, Shouzhi Pu, Zhiyong Wang* A silver(I)-catalyzed tandem reaction of 2-alkynylbenzaldoxime with ketene. Org. Biomol. Chem. 2013, 11, 2898. 

[24] Danqing Zheng, Zhiyong Wang*, Jie Wu* Silver triflate catalyzed reaction of 2-alkynylbenzaldoxime with phenol: a general and facile route to 1-aroxyisoquinolines, Synthesis, 2011, 2810.

 

独立工作前发表的文章:

[1] Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin* Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells. Angew. Chem. Int. Ed. 2012, 51, 10600.

[2] Avinash Muppidi, Zhiyong Wang, Xiaolong Li, Jiandong Chen, Qing Lin* Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx. Chem. Commun. 2011, 47, 9396.

[3] Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu* Pd-catalyzed decarboxylative couplings of arenecarboxylic acids with aryl iodides. Tetrahedron 2009, 65, 4635.

[4] Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu* Pd-catalyzed decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide. Org. Biomol. Chem. 2009, 7, 863.

[5] Zhiyong Wang, Xiaoyu Sun, Shengqing Ye, Weizi Wang, Bing Wang, Jie Wu* Quinine-catalyzed enantioselective desymmetrization of meso-aziridines with benzenethiols. Tetrahedron: Asymmetry 2008, 19, 964.

[6] Zhiyong Wang, Xiaoyu Sun, Jie Wu* FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines. Tetrahedron 2008, 64, 5013.

[7] Zhiyong Wang, Jie Wu* Synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-ones via Pd-catalyzed region-selective cross-coupling reaction and cyclization. Tetrahedron 2008, 64, 1736.

[8] Zhiyong Wang, Renhua Fan, Jie Wu* Pd-catalyzed regioselective cross-coupling reactions of 3-bromo-4-tosyloxyquinolin-2(1H)-one with arylboronic acids. A facile and convenient route to 3, 4-disubstituted quinolin-2(1H)-ones. Adv. Synth. Catal. 2007, 349, 1943.

[9] Zhiyong Wang, Bing Wang, Jie Wu* Diversity-oriented synthesis of functionalized quinolin-2(1H)-ones via Pd-catalyzed site-selective cross-coupling reactions. J. Comb. Chem. 2007, 9, 811.

[10] Zhiyong Wang, Gang Zou*, Jie Tang. An unprecedented rhodium-catalyzed self-conjugate reduction, cross-coupling tandem reaction of cinnamaldehydes with arylboronic acids. Chem. Commun. 2004, 1192.

[11] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang. Rhodium-catalyzed Heck-type reaction of arylboronic acids with α, β-unsaturated esters: tuning β-hydrogen elimination vs. hydrolysis of alkylrhodium species. Chem. Commun. 2003, 2438.

[12] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang, Mingyuan He. Developing an ionic medium for ligandless-palladium-catalyzed Suzuki and Heck couplings. J. Mol. Cata. A: Chemical 2003, 206, 193.

 

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