K.C. Nicolaou 合成有机及生物有机化学专业教授。1969-1972年,以第一名的荣誉在Bedford College获理学学士学位;1972-1973年,获得英国University College博士学位, 师从F. Sondheimer教授和P. J. Garratt教授;1972-1973年,他在哥伦比亚大学进行博士后研究,师从E. J. Kazt教授;1973-1976年,在哈佛大学进行博士后研究,师从诺贝尔奖获得者 E. J. Corey教授。 |
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研究方向
K. C. Nicolaou教授的研究兴趣涉及化学、生物学和药学等多个方面。他领导的研究小组致力于结构新颖且具有重要生物活性的天然产物全合成,并通过发展新合成策略和合成方法将新合成技术应用于生物学和新药研发。作为第一作者或合作者,K. C. Nicolaou教授已发表超过725篇科研论文及综述,申请专利79项(56个获批,23个待批),并撰写5本专著。
代表性论文、专著和专利
[1] Invigorating Education, K.C. Nicolaou, Angew. Chem. Int. Ed. 2011, 50, 63–74.
[2] Synthesis of the C'D'E'F' Domain of Maitotoxin, K C. Nicolaou, J.H. Seo, T. Nakamura, R.J. Aversa, J. Am. Chem. Soc. 2011, 133, 214–219.
[3] Synthesis of the WXYZA' Domain of Maitotoxin, K C. Nicolaou, T.M. Baker, T. Nakamura, J. Am. Chem. Soc.2011, 133, 220–226.
[4] Total Synthesis and Biological Evaluation of Monorhizopodin and 16-epi-Monorhizopodin, K.C. Nicolaou, X. Jiang, P.J. Lindsay-Scott, A. Corbu, S. Yamashiro, A. Bacconi, V.M. Fowler, Angew. Chem. Int. Ed. 2011, 50, 1139–1144
[5] Total Synthesis and Biological Evaluation of Marinopyrrole A and Analogs, K.C. Nicolaou, N.L. Simmons, J.S. Chen, N.M. Haste, V. Nizet, Tetrahedron Lett. 2011, 52, 2041–2043.
[6] Design, Synthesis and Biological Evaluation of a Biyouyanagin Library, K.C. Nicolaou, S. Sanchini, D. Sarlah, G. Lu, D.K. Nomura, B.F. Cravatt, B. Cubitt, J.C. de la Torre, A.J. Hessell, D.R. Burton, Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6715–6720.
[7] Addressing the Stereochemistry of Complex Organic Molecules by Density Functional Theory-NMR: Vannusal B in Retrospective, G. Saielli, K.C. Nicolaou, A. Ortiz, H. Zhang, A. Bagno, J. Am. Chem. Soc. 2011, 133, 6072–6077.
[8] An Expedient Synthesis of a Functionalized Core Structure of Bielschowskysin, K.C. Nicolaou, V.A. Adsool, C.R.H. Hale, Angew. Chem. Int. Ed. 2011, 50, 5149–5152.
[9] Enantioselective Dichlorinatoin of Allylic Alcohols, K.C. Nicolaou, N.L. Simmons, Y. Ying, P.M. Heretsch, J.S. Chen, J. Am. Chem. Soc. 2011, 133, 8134–8137.
[10] Total Synthesis of Epicoccin G, K.C. Nicolaou, S. Totokotsopoulos, D. Giguère, Y. Sun, D. Sarlah, J. Am. Chem. Soc. 2011, 133, 8150–8153.
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