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王治永 博士/副教授,硕士生导师,研究方向为有机合成化学和药物合成2009年毕业于复旦大学化学系有机化学专业,获理学博士学位;20098-20108月在美国纽约州立大学布法罗分校从事博士后研究。201011月进入重庆大学化学化工学院工作。

 

 

研究方向

  有机合成方法学:生物活性杂环的高效构建及衍生化

1)发展新型、高效的串联反应构建具有潜在生物活性的复杂环状骨架小分子化合物;

2)发展新型金属促进的高选择性催化反应;

  新型有机固体光电材料的制备及性能研究

  药物的创新合成技术研究

 

联系方式 E-mailzwang@cqu.edu.cn;实验室:理科楼LC721

 

发表文章:

[1]     Zhiyong Wang(大三学生)Yanzhou Yang, Fang Gao, Zhiyong Wang*, Qian Luo, Ling Fang*. A Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4 + 1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes. Org. Lett. 2018, 20, 934. (IF = 6.579)

[2]     Ling Fang, Liun Xue, Peng Yang, Zhiyong Wang*. A Facile Route to 4-Polyfluoroarylquinolin-2(1H)-ones and 4-Polyfluoroarylcoumarins via C-H Bond Activation. Chem. Lett. 2017, 46, 1223. (IF = 1.801)

[3]     Zhen Chen, Zhiyong Wang*. An efficient route to diverse 2H-pyrano[3,2-c]quinolin-5(6H)- ones via electrophilic cyclization reactions. Tetrahedron, 2016, 72, 4288. (IF=2.651)

[4]     Zhiyong Wang*, Liun Xue, Yiyi He, Ling Fang*. Access to Functionalized 3H-Pyrrolo[2,3-c]quinolin-4(5H)-ones and  Thieno[2,3-c]quinolin-4(5H)-ones via Domino Reaction of 4-Alkynyl-3-bromo-quinolin-2(1H)-ones. J. Org. Chem. 2014, 79, 9628. (IF = 4.638)

[5]     Xianbo Wang, Liun Xue, Zhiyong Wang*. A Copper-Catalyzed Three-Component Reaction of Triethoxysilanes, Sulfur Dioxide, and Hydrazines. Org. Lett. 2014, 16, 4056. (IF = 6.324)

[6]     Xianbo Wang, Zhiyong Wang*. A tandem reaction of 2-alkynylbenzaldoximes with cyclic ethers co-catalyzed by silver(I) triflate and copper(II) acetate. Tetrahedron 2014, 70, 6728. (IF = 2.817)

[7]     Xianbo Wang, Zhiyong Wang*. An approach to 1-phosphorylated isoquinolines through silver(I)-catalyzed tandem reaction involving C–N and C–P bond formation. Tetrahedron 2014, 70, 5720. (IF = 2.817)

[8]     Zhiyong Wang*, Xiaoxiao Xing, Liun Xue, Yan Xiong, Ling Fang*. Iron(III) Chloride Catalyzed Formation of Aryl Hydrazides from Electron-Rich Arenes and Azodicarboxylates, Synthesis 2014, 757. (IF = 2.443)

[9]     Hongliang Liu, Zhiyong Wang*, Shouzhi Pu, Gang Liu*. Synthesis of H-Pyrazolo[5,1-a]isoquinolines via Silver(I)-Catalyzed Tandem Reaction of N′-(2-Alkynylbenzylidene)hydrazides with Propargyl Amine Derivatives. Synthesis 2014, 600. (IF = 2.443)

[10] Zhiyong Wang,* Xiaoxiao Xing, Lijun Xue, Fang Gao, Ling Fang*. Synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-ones via Pd-catalyzed cross-coupling reaction and cyclization. Org. Biomol. Chem. 2013, 11, 7334. (IF = 3.487)

[11] Hongliang Liu, Gang Liu*, Shouzhi Pu, Zhiyong Wang*. A silver(I)-catalyzed tandem reaction of 2-alkynylbenzaldoxime with ketene. Org. Biomol. Chem. 2013, 11, 2898. (IF = 3.487)

[12] Danqing Zheng, Zhiyong Wang*, Jie Wu*. Silver triflate catalyzed reaction of 2-alkynylbenzaldoxime with phenol: a general and facile route to 1-aroxyisoquinolines, Synthesis, 2011, 2810. (IF = 2.443)

 

独立工作前发表的文章:

[1]     Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* and Qing Lin*. Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells. Angew. Chem. Int. Ed. 2012, 51, 10600.

[2]     Avinash Muppidi, Zhiyong Wang, Xiaolong Li, Jiandong Chen, Qing Lin*. Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx. Chem. Commun. 2011, 47, 9396.

[3]     Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu*. Pd-catalyzed decarboxylative couplings of arenecarboxylic acids with aryl iodides. Tetrahedron 2009, 65, 4635.

[4]     Zhiyong Wang, Qiuping Ding, Xiaodan He, Jie Wu*. Pd-catalyzed decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide. Org. Biomol. Chem. 2009, 7, 863.

[5]     Zhiyong Wang, Xiaoyu Sun, Shengqing Ye, Weizi Wang, Bing Wang, Jie Wu*. Quinine-catalyzed enantioselective desymmetrization of meso-aziridines with benzenethiols. Tetrahedron: Asymmetry 2008, 19, 964.

[6]     Zhiyong Wang, Xiaoyu Sun, Jie Wu*. FeCl3: an efficient catalyst for reactions of electron-rich arenes with imines or aziridines. Tetrahedron 2008, 64, 5013.

[7]     Zhiyong Wang, Jie Wu*. Synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-ones via Pd-catalyzed region-selective cross-coupling reaction and cyclization. Tetrahedron 2008, 64, 1736.

[8]     Zhiyong Wang, Renhua Fan, Jie Wu*. Pd-catalyzed regioselective cross-coupling reactions of 3-bromo-4-tosyloxyquinolin-2(1H)-one with arylboronic acids. A facile and convenient route to 3, 4-disubstituted quinolin-2(1H)-ones. Adv. Synth. Catal. 2007, 349, 1943.

[9]     Zhiyong Wang, Bing Wang, Jie Wu*. Diversity-oriented synthesis of functionalized quinolin-2(1H)-ones via Pd-catalyzed site-selective cross-coupling reactions. J. Comb. Chem. 2007, 9, 811.

[10] Zhiyong Wang, Gang Zou*, Jie Tang. An unprecedented rhodium-catalyzed self-conjugate reduction, cross-coupling tandem reaction of cinnamaldehydes with arylboronic acids. Chem. Commun. 2004, 1192.

[11] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang. Rhodium-catalyzed Heck-type reaction of arylboronic acids with α, β-unsaturated esters: tuning β-hydrogen elimination vs. hydrolysis of alkylrhodium species. Chem. Commun. 2003, 2438.

[12] Gang Zou*, Zhiyong Wang, Junru Zhu, Jie Tang, Mingyuan He. Developing an ionic medium for ligandless-palladium-catalyzed Suzuki and Heck couplings. J. Mol. Cata. A: Chemical 2003, 206, 193.

 

研究生获奖:

[1]     11级邢晓晓:2013年硕士研究生国家奖学金

[2]     12级薛丽俊:2014年硕士研究生国家奖学金

 

近期主持的科研项目:

[1]      重庆大学人才引进科研启动基金 (2011.01-2015.12)

[2]      重庆市自然科学基金面上项目 (2011.09-2014.07)

[3]      教育部留学回国人员启动基金 (2013.07-2015.07)

[4]      中央高校基本科研业务费科研专项自然科学类项目 (2013.06-2014.06)

[5]      国家自然科学基金青年基金项目 (2014.01-2016.12)

[6]      重庆市基础与前沿研究计划项目 (2015.08-2018.07)

 

欢迎对有机化学、药物化学感兴趣的同学加入本课题组!