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​蓝宇
2017-04-13 10:16   审核人:

    

蓝宇 男,1981年生,重庆大学化学化工学院教授\特聘研究员\博士生导师,研究方向为有机化学理论和理论有机化学。蓝宇2003年北京大学化学与分子工程学院获得学士学位,同年继续在北京大学化学与分子工程学院硕博连读,从师于中国科学院院士吴云东教授,专攻理论有机化学,2008年获得理学博士学位。蓝宇2009年至2012年在美国加州大学洛杉矶分校(University of California, Los Angles)从事博士后科研工作,从师于美国科学院院士,K. N. Houk教授,继续研究理论有机化学。20124月以青年百人计划特聘研究员加入重庆大学化工学院工作,并于20169月转入终身制。在独立工作期间,本人以通讯作者身份在包括Accounts Chem. Res.1篇,IF = 20.27)、J. Am. Chem. Soc.6篇,IF = 13.86)、Angew. Chem. Int. Ed.9篇,IF = 11.99)、Nature Commun.4篇,IF = 12.12)、Chem. Sci.3篇,IF = 8.67)、ACS Catal.5篇,IF = 10.61)、Sci. Adv.1篇)等期刊发表科研论文共计80余篇(含已接收),通讯作者论文累计被他人正面引用达1000余次,全部论文累计被引用达2000余次,目前蓝宇H因子为27。蓝宇博士的Research IDA-8146-2016http://www.researcherid.com/rid/A-8146-2016)。蓝宇博士曾经或正在主持国家自然科学基金面上项目2项、青年项目1项。蓝宇荣获“2016年中国化学会青年化学奖。此外,蓝宇还荣获“2015年中国化学会-物理有机化学新人奖

 

Dr. Yu Lan, professor in organic chemistry, joined the college of chemistry and chemical engineering of Chongqing University in April, 2012. Dr. Lan was born in 1981 and got his B.S. and Ph.D degrees in Peking University in 2003 and 2008, respectively. Dr. Lan was a postdoctoral research associate in University of California, Los Angeles in US during 2009-2012. His research includes the mechanistic understanding of transition metal catalyzed C-H activations, cross-couplings, and C-C bond formation reactions; ligand effects in organometallic compounds; design of metal catalyzed cyclization reactions; organic reactions catalyzed by metal-containing enzymes; and theoretical investigation of pericyclic reactions.

Over the past 4 years, as the corresponding author, Dr. Lan have published 80 research articles. Among them, the impact factors (IF) of 28 papers are greater than 9.0, including one in Accounts Chem. Res., six in J. Am. Chem. Soc., nine in Angew. Chem. Int. Ed., four in Nature Comm., three in Chem. Sci., and five in ACS Catal.. Additionally, Dr. Lan also published two cover articles in Scientia Sinica Chimica by the invitation of editor. Dr Lan’s publications have been cited more than 2000 times, and the highest frequency of citation is more than 140. Dr. Lan’s Research ID is A-8146-2016 (http://www.researcherid.com/rid/A-8146-2016). Dr. Lan’s H-index is 27.

Dr. Lan has got “2016 Chinese Chemical Society Award for Outstanding Young Chemist”. He also has got “2015 Chinese Chemical Society, Physical Organic Chemistry Newcomer Award”.

 

联系方式(Email) lanyu@cqu.edu.cn

 

研究方向:主要研究领域为有机化学、金属有机化学、理论有机化学、计算化学,包括但不限于

   1. 金属有机化学反应的机理研究,碳氢键活化、碳碳键活化以及交叉偶联反应;

   2. 金属有机化学及配体的理论研究与设计,不对称催化反应的理论研究;

   3. 酶催化化学反应机理研究;

   4. 周环反应的机理研究;

   5. 新型碳材料化学修饰的理论研究。

 

获得奖励

   1. 2016年中国化学会青年化学奖

   2. 2015年中国化学会-物理有机化学新人奖

 

基金支持:

5. 2018~2021      国家自然科学基金面上项目 《铜催化偶联反应中Cu(III)中间体生成机制的理论研究》,基金编号21772020

4. 2015~2016      中央高校基本科研重大项目 《新型碳材料功能化的理论研究》(已结题,优秀),基金编号106112015CDJZR228806

3. 2014~2017      国家自然科学基金面上项目 《铑催化碳-硅键、碳-碳键断裂生成机理的理论研究》,基金编号21372266

2. 2014~2017    国家自然科学基金青年项目 《单层石墨烯化学方法修饰的理论研究》(已结题),基金编号51302327

1. 2012~2016      重庆大学青年百人计划启动经费 《理论有机化学》

 

代表论文:

(一)通讯作者论文

(80) “Ni(I)–Ni(III) vs Ni(II)–Ni(IV): Mechanistic Study of Ni-catalyzed Alkylation of Benzamides with Alkyl Halides” Li, Y.; Zou, L.; Bai, R.*; Lan, Y.* Org. Chem. Front. 2017, 4, accepted. (DOI: 10.1039/C7QO00850C)

(79) “On the Mechanism of Copper-Catalyzed Oxytrifluoromethylation of Allylamines with CO2: A Computational Study” Zhu, L.; Ye, J.-H.; Duan, M.; Qi, X.; Yu, D.-G.*; Bai, R.*; Lan, Y.* Org. Chem. Front. 2017, 4, accepted. (DOI: 10.1039/C7QO00838D)

(78) “Reactivity and regioselectivity in Diels–Alder reactions of anion encapsulated fullerenes” Cui, C.-X.; Zhang, Z.-P.; Zhu, L.; Qu, L.-B.; Zhang, Y.-P.; Lan, Y.* Phys. Chem. Chem. Phys. 2017, 42, (DOI: 10.1039/C7CP06365B)

(77) “C(sp2)-C(sp2) Reductive Elimination from Well-Defined Diarylgold(III) Complexes” Kang, K.; Liu, S.; Xu, T.; Wang, D.; Leng, X.; Bai, R.; Lan, Y.*; Shen, Q.* Organometallics 2017, 36, accepted. (DOI:)

(76) “Mechanism of Rhodium-Catalyzed C−H Functionalization: Advances in Theoretical Investigation” Qi, X.; Li, Y.; Bai, R.; Lan, Y.* Acc. Chem. Res. 2017, 50, ASAP. (DOI: 10.1021/acs.accounts.7b00400)

(75) “Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO2” Ye. J.-H.; Zhu, L.; Yan, S.-S.; Miao, M.; Zhang, X.-C.; Zhou, W.-J.; Li, J.; Lan, Y.*; Yu, D.-G.* ACS Catal. 2017, 7, 8324−8330. (DOI: 10.1021/acscatal.7b02533)

(74) “Rhodium/Copper Cocatalyzed Highly trans-Selective 1,2- Diheteroarylation of Alkynes with Azoles via C−H Addition/Oxidative Cross-Coupling: A Combined Experimental and Theoretical Study” Tan, G.; Zhu, L.; Liao, X.; Lan, Y.*; You, J.* J. Am. Chem. Soc. 2017, 139, 15724-15737. (DOI: 10.1021/jacs.7b07242)

(73) “Nine-Membered Benzofuran-Fused Heterocycles: Enantioselective Synthesis by Pd-Catalysis and Rearrangement via Transannular Bond Formation” Rong, Z.-Q.; Yang, L.-C.; Liu, S.; Yu, Z.; Wang, Y.-N.; Tan, Z. Y.; Huang, R.-Z.; Lan, Y.*; Zhao, Y.* J. Am. Chem. Soc. 2017, 139, 15304-15307. (DOI: 10.1021/jacs.7b09161)

(72) “Mechanistic Study on the Fluoride-induced Activation of Kobayashi Precursor: pseudo-SN2 Pathway via a PentaCoordinated Silicon ate-Complex” Liu, S.; Li, Y.*; Lan, Y.* Eur. J. Org. Chem. 2017, 42, accepted. (DOI: 10.1002/ejoc.201701249)

(71) “Cp*CoIII-Catalyzed Branch-Selective Hydroarylation of Alkynes via C−H Activation: Efficient Access to α-gem-Vinylindoles” Zhou, X.; Luo, Y.; Kong, L.; Xu, Y.; Zheng, G.; Lan, Y.*; Li, X.* ACS Catal. 2017, 7, 7296-7304. (DOI: 10.1021/acscatal.7b02248)

(70) “Bond dissociation energy controlled σ-bond metathesis in alkaline-earth-metal hydride catalyzed dehydrocoupling of amines and boranes: a theoretical study” Xu, D.; Shan, C.; Li, Y.; Qi, X.; Luo, X.*; Bai, R.*; Lan, Y.* Inorg. Chem. Front. 2017, 4, 1813. (DOI: 10.1039/c7qi00459a)

(69) “From Mechanistic Study to Chiral Catalyst Optimization: Theoretical Insight into Binaphthophosphepine-catalyzed Asymmetric Intramolecular [3+2] Cycloaddition” Duan, M.; Zhu, L.; Qi, X.; Yu, Z.; Li, Y.; Bai, R.*; Lan, Y.* Sci. Rep. 2017, 7, 7619. ( DOI:10.1038/s41598-017-07863-9)

(68) “Catalyst-controlled regioselectivity in phosphine catalysis: the synthesis of spirocyclic benzofuranones via regiodivergent [3+2] annulations of aurones and an allenoate” Ni, H.; Yu, Z.; Yao, W.; Lan, Y.*; Ullah, N.*; Lu, Y.* Chem. Sci. 2017, 8, 5699-5704. (DOI: 10.1039/c7sc02176c)

(67) “Mechanistic insights into copper-catalyzed trifluoromethylation of aryl boronic acids: a theretical study.” He, X.; Shan, C.; Qi, X.*; Bai, R.*; Lan, Y.* Sci. Sin. Chem. 2017, 47, 859-864. (DOI: 10.1360/N032017-00056)

(66) “Ir(III)/Ir(V) or Ir(I)/Ir(III) Catalytic Cycle? Steric-Effect-Controlled Mechanism for the para-C−H Borylation of Arenes” Zhu, L.; Qi, X.; Li, Y.; Duan, M.; Zou, L.; Bai, R.*; Lan, Y.* Organometallics 2017, 36, 2107-2115. (DOI: 10.1021/acs.organomet.7b00151)

(65) “Chiral phosphine-mediated intramolecular [3+2] annulation: enhanced enantioselectivity by achiral Brønsted acid” Yao, W.; Yu, Z.; Wen, S.; Ni, H.; Ullah, N.*; Lan, Y.*; Lu, Y.* Chem. Sci. 2017, 8, 5196-5200. (DOI: 10.1039/c7sc00952f)

(64) “Enantioselective alkynylation of N-sulfonyl a-ketiminoesters via a Friedel–Crafts alkylation strategy” Liu, R.-R.; Zhu, L.; Hu, J.-P.; Lu, C.-J.; Gao, J.-R.; Lan, Y.*; Jia, Y.-X.* Chem. Commun. 2016, 52, 5890-5893. (DOI: 10.1039/c7cc01015j)

(63) “Bioinspired Total Synthesis of Homodimericin” A Huang, J.; Gu, Y.; Guo, K.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 7890-7894. ( DOI: 10.1002/anie.201702768)

(62) “Mechanism, Regio-, and Diastereoselectivity of Rh(III)-Catalyzed Cyclization Reactions of N‑Arylnitrones with Alkynes: A Density Functional Theory Study” Li, Y.; Shan, C.; Yang, Y.-F.; Shi, F.; Qi, X.; Houk, K. N.*; Lan, Y.* J. Phys. Chem. A 2017, 121, 4496-4504. ( DOI: 10.1021/acs.jpca.7b01020)

(61) “Bioinspired Asymmetric Synthesis of Hispidanin” A Li, F.; Tu, Q.; Chen, S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* Angew. Chem. Int. Ed. 2017, 56, 5844-5848. (DOI: 0.1002/anie.201700838)

(60) “C−O Functionalization of α‑Oxyboronates: A Deoxygenative gemDiborylation and gem-Silylborylation of Aldehydes and Ketones” Wang, L.; Zhang, T.; Sun, W.; He, Z.; Xia, C.; Lan, Y.*; Liu, C.* J. Am. Chem. Soc. 2017, 139, 5257-5264. (DOI: 10.1021/jacs.7b02518)

(59) “Mononuclear or Dinuclear? Mechanistic Study of the ZincCatalyzed Oxidative Coupling of Aldehydes and Acetylenes” Yue, X.; Qi, X.; Bai, R.; Lei, A.*; Lan, Y.* Chem. Eur. J. 2017, 23, 6419-6425. (DOI: 10.1002/chem.201700733)

(58) “Mechanism of Alkaline Earth Metal Catalyzed Hydroboration of Carbodiimides: A Theoretical Study” Xu, D.; Shan, C.; Bai, R.*; Lan, Y.* Chin. J. Org. Chem. 2017, 37, 1231-1236. (DOI: 10.6023/cjoc201701033)

(57) “Regioselective a-Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins” Wu, B.; Yu, Z.; Gao, X.; Lan, Y.*; Zhou, Y.* Angew. Chem. Int. Ed. 2017, 56, 4006-4010. (DOI:10.1002/anIe.201700437)

(56) “Stabilization of Two Radicals with One Metal: A Stepwise Coupling Model for Copper-Catalyzed Radical–Radical Cross-Coupling” Qi, X.; Zhu, L.; Bai, R.*; Lan, Y.* Sci. Rep. 2017, 7, 43579. (DOI: 10.1038/srep43579)

(55) “Thiolate–palladium(IV) or sulfonium–palladate(0)? A theoretical study on the mechanism of palladium-catalyzed C–S bond formation reactions” Xu, D.; Qi, X.; Duan, M.; Yu, Z.; Zhu, L.; Shan, C.; Yue, X.; Bai, R.*; Lan, Y.* Org. Chem. Front. 2017, 4, 943-950. (DOI: 10.1039/c6qo00841k)

(54) “Room-Temperature Coupling/Decarboxylation Reaction of α‑Oxocarboxylates with α‑Bromoketones: Solvent-Controlled Regioselectivity for 1,2- and 1,3-Diketones” He, Z.; Qi, X.; She, Z.; Zhao, Y.; Li, S.; Tang, J.; Gao, G.*; Lan, Y.*; You, J.* J. Org. Chem. 2017, 82, 1403-1411. (DOI: 10.1021/acs.joc.6b02575)

(53) “Application of Gausian Software in Organic Chemistry Teaching in Senior High School” Li, Y.;* Qi, X.; Lan, Y.* Chin. J. Chem. Edu. 2017, 38(13), 43. (DOI: 10.13884/J.1003-3807hxjy.2016120022)

(52) “Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone” A Han, Y.; Jiang, Y.; Li, Y.; Yu, H.; Tong, B.; Niu, Z.; Zhou, S.; Liu, S.; Lan, Y.;* Chen, J.;* Yang, Z.;* Nat. Commun. 2017, 8, 14233. (DOI: 10.1038/ncomms14233)

(51) “Ligand effect on nickle-catalyzed reductive alkyne-aldehyde coupling reactions: a computational study. ” Luo, X.; Li, Y.; Qi, X.; Zhu, L.; Chen, C.;* Lan, Y.* Sci. Sin. Chem. 2017, 47, 341-349. (DOI:10.1360/N032016-00129)

(50) “Computational Investigation of the Role Played by Rhodium(V) in the Rhodium(III)-Catalyzed ortho-Bromination of Arenes” Zhang, T.; Qi, X.; Liu, S.; Bai, R.; * Liu, C.; * Lan, Y.* Chem.-Eur. J. 2017, 23, 2690-2699. (DOI: 10.1002/chem.201605188)

(49) “Readily Accessible and Highly Efficient Ferrocene-Based AminoPhosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones” Yu, J.; Duan, M.; Wu, W.;Qi, X. ; Xue, P.; Lan, Y.;* Dong, X-Q.;* Zhang, X.;* Chem.-Eur. J. 2017, 23, 970-975. (DOI: 10.1002/chem.201604855)

(48) “C8–H bond activation vs. C2–H bond activation: from naphthyl amines to lactams” Shi, R.; Lu, L.; Xie, H.; Yan, J.; Xu, T.; Zhang, H.; Qi, X.; Lan, Y.*; Lei, A.* Chem. Commun. 2016, 52, 13307. ( DOI: 10.1039/c6cc06358f)

(47) “Mild Acylation of C(sp3)−H and C(sp2)−H Bonds under Redox-Neutral Rh(III) Catalysis” Yu, S.; Li, Y.; Kong, L.; Zhou, X.; Tang, G.; Lan, Y.;* Li, X.* ACS Catal. 2016, 6, 7744-7748. (DOI: 10.1021/acscatal.6b02668)

(46) “Effective Chirality Transfer in [3+2] Reaction between AllenylRhodium and Enal: Mechanistic Study Based on DFT Calculations” Qi, X.; Liu, S.; Zhang, T.; Long, R.; Huang, J.; Gong, J.; Yang, Z.;* Lan, Y.* J. Org. Chem. 2016, 81, 8306-8311. (DOI: 10.1021/acs.joc.6b01429)

(45) “Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity are Influenced by the Hydrogen Donor” Pan, H. J.; Zhang, Y.; Shan, C.; Yu, Z.; Lan, Y.;* Zhao, Y.* Angew. Chem. Int. Ed. 2016, 55, 9615-9619. (DOI:10.1002/anie.201604025)

(44) “Reactivity of Single-Walled Carbon Nanotubes in the Diels–Alder Cycloaddition Reaction: Distortion–Interaction Analysis along the Reaction Pathway” Li, Y.; Osuna, S.; Garcia-Borràs, M.; Qi, X.; Liu, S.; Houk, K. N.;* Lan, Y.* Chem.-Eur. J. 2016, 22, 12819-12824. (DOI: 10.1002/chem.201601799)

(43) “Iridium Catalysts with f‑Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones” Wu, W.; Liu, S.; Duan, M.; Tan, X.; Chen, C.; Xie, Y.; Lan, Y.;* Dong, X.-Q.; Zhang, X.* Org. Lett. 2016, 18, 2938-2941. (DOI: 10.1021/acs.orglett.6b01290)

(42) “Computational Studies on an Aminomethylation Precursor: (Xantphos)Pd(CH2NBn2)+” Qi, X.; Liu, S.; Lan, Y.* Organometallics 2016, 35, 1582-1585. (DOI: 10.1021/acs.organomet.6b00234)

(41) “Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp3)-H and C(sp2)-H under Rhodium(III) Catalysis” Yu, S.; Tang, G.; Li, Y.; Zhou, X.; Lan, Y.;* Li, X.* Angew. Chem. Int. Ed. 2016, 55, 8696-8700. (DOI: 10.1002/anie.201602224)

(40) “Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones” He, Y.;* Agarwal, P. K.; Kiran, I. N.; Yu, R.; Cao, B.; Zou, C.; Zhou, X.; Xu, H.; Xu, B.; Zhu, L.; Lan, Y.;* Nicolaou, K. C.* Chem.-Eur. J. 2016, 22, 7696-7701. (DOI: 10.1002/chem.201601471)

(39) “Regio- and Stereoselective Syntheses of 7-Oxabicyclo[2.2.1]heptanes via a Gold(I)-Catalyzed Cycloisomerization of Alkynediols: Asymmetric Total Synthesis of Farnesiferol C” Gu, Y.-Q.; Zhang, P.-P.; Fu, J.-K.; Liu, S.; Lan, Y.*; Gong, J.-X.*; Yang, Z.* Adv. Synth. Catal. 2016, 358, 1392-1397. (DOI: 10.1002/adsc.201600218)

(38) “Mechanism of Ruthenium-Catalyzed Direct Arylation of C−H Bonds in Aromatic Amides: A Computational Study” Shan, C.; Luo, X.; Qi, X.; Liu, S.; Li, Y.; Lan, Y.* Organometallics 2016, 35, 1440-1445. (DOI: 10.1021/acs.organomet.6b00064)

(37) “Rhodium-Catalyzed Cyclocarbonylation of Ketimines via C−H Bond Activation” Gao, B.; Liu, S.; Lan, Y.*; Huang, H.* Organometallics 2016, 35, 1480-1487. (DOI: 10.1021/acs.organomet.6b00072)

(36) “Mechanism of Rhodium-Catalyzed Formyl Activation: A Computational Study” Luo, X.; Bai, R.; Liu, S.; Shan, C.; Chen, C.; Lan, Y.* J. Org. Chem. 2016, 81, 2320-2326. (DOI: 10.1021/acs.joc.5b02828)

(35) “Mechanism and electronic effect for the synthesis of 6-aroylated phenanthridines: a theoretical study” Xu, T.; Qi, X.; Lan, Y.* Sci. Sin. Chem. 2016, 46, 616-622. (DOI: 10.1360/N032015-00217)

(34) “Rhodium-Catalyzed Hetero-(5+2) Cycloaddition of Vinylaziridines and Alkynes: A Theoretical View of the Mechanism and Chirality Transfer” Zhu, L.; Qi, X.; Lan, Y.* Organometallics 2016, 35, 771-777. (DOI: 10.1021/acs.organomet.6b00007)

(33) “Rhodium(III)-Catalyzed Annulation between N‑Sulfinyl Ketoimines and Activated Olefins: C−H Activation Assisted by an Oxidizing N−S Bond” Wang, Q.; Li, Y.; Qi, Z.; Xie, F.; Lan, Y.*; Li, X.* ACS Catal. 2016, 6, 1971-1980. (DOI: 10.1021/acscatal.5b02297)

(32) “Gold(I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization” Jin, S.; Jiang, C.; Peng, X.; Shan, C.; Cui, S.; Niu, Y.; Liu, Y.; Lan, Y.*; Liu, Y.*; Cheng, M.* Org. Lett. 2016, 18, 680-683. (DOI: 10.1021/acs.orglett.5b03641)

(31) “Mechanism of Synergistic Cu(II)/Cu(I)-Mediated Alkyne Coupling: Dinuclear 1,2-Reductive Elimination after Minimum Energy Crossing Point” Qi, X.; Bai, R.; Zhu, L.; Jin, R.; Lei, A.; Lan, Y.* J. Org. Chem. 2016, 81, 1654-1660. (DOI: 10.1021/acs.joc.5b02797)

(30) “Iron-Catalyzed Decarboxylative (4+1) Cycloadditions: Exploiting the Reactivity of Ambident Iron-Stabilized Intermediates” Wang, Q.; Qi, X.; Lu, L. Q.*; Li, T. R.; Yuan, Z. G.; Zhang, K.; Li, B. J.; Lan, Y.*; Xiao, W. J.* Angew. Chem. Int. Ed. 2016, 55, 2840-2844. (DOI: 10.1002/anie.201510413)

(29) “Regiodivergent Enantioselective γ‑Additions of Oxazolones to 2,3-Butadienoates Catalyzed by Phosphines: Synthesis of α,α-Disubstituted α‑Amino Acids and N,O‑Acetal Derivatives” Wang, T.; Yu, Z.; Hoon, D. L.; Phee, C. Y.; Lan, Y.*; Lu, Y.* J. Am. Chem. Soc. 2016, 138, 265-271. (DOI: 10.1021/jacs.5b10524)

(28) “Mechanism, chemoselectivity and enantioselectivity for the rhodium-catalyzed desymmetric synthesis of hydrobenzofurans: a theoretical study” Yu, Z.; Qi, X.; Li, Y.; Liu, S.; Lan, Y.* Org. Chem. Front. 2016, 3, 209-216. (DOI: 10.1039/c5qo00334b)

(27) “Copper-catalyzed aerobic oxidative coupling: From ketone and diamine to pyrazine” Wu, K.; Huang, Z.; Qi, X.; Li, Y.; Zhang, G.; Liu, C.; Yi, H.; Meng, L.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.*; Lei, A.* Sci. Adv. 2015, 1, e1500656. (DOI: 10.1126/sciadv.1500656)

(26) “Silver Migration Facilitates Isocyanide-Alkyne [3+2] Cycloaddition Reactions: Combined Experimental and Theoretical Study” Qi, X.; Zhang, H.; Shao, A.; Zhu, L.; Xu, T.; Gao, M.*; Liu, C.*; Lan, Y.* ACS Catal. 2015, 5, 6640-6647. ( DOI: 10.1021/acscatal.5b02009)

(25) “Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction” Fu, J.; Gu, Y.; Yuan, H.; Luo, T.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2015, 6, 8617. (DOI: 10.1038/ncomms9617)

(24) “Development of a Rhodium(II)-Catalyzed Chemoselective C(sp3)-H Oxygenation” Lin, Y.; Zhu, L.; Lan, Y.*; Rao, Y.* Chem.-Eur. J. 2015, 21, 14937-14942. (DOI: 10.1002/chem.201502140.)

(23) “Diastereoselective Synthesis of Cyclopentanoids: Applications to the Construction of the ABCD Tetracyclic Core of Retigeranic Acid” A Zhang, J.; Wang, X.; Li, S.; Li, D.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Chem.-Eur. J. 2015, 21, 12596-12600. (DOI: 10.1002/chem.201502423)

(22) “Distortion–interaction analysis along the reaction pathway to reveal the reactivity of the Alder-ene reaction of enes” Jin, R.; Liu, S.; Lan, Y.* RSC Adv. 2015, 5, 61426-61435. (DOI: 10.1039/c5ra10345b)

(21) “Highly enantioselective construction of tertiary thioethers and alcohols via phosphine-catalyzed asymmetric g-addition reactions of 5H-thiazol-4- ones and 5H-oxazol-4-ones: scope and mechanistic understandings” Wang, T.; Yu, Z.; Hoon, D. L.; Huang, K.-W.; Lan, Y.*; Lu, Y.* Chem. Sci. 2015, 6, 4912-4922. (DOI: 10.1039/c5sc01614b)

(20) “Mechanism and selectivity for zinc-mediated cycloaddition of azides with alkynes: a computational study” Li, Y.; Qi, X.; Lei, Y.; Lan, Y.* RSC Adv. 2015, 5, 49802-49808. (DOI: 10.1039/c5ra02703a)

(19) “The Mechanism of N-O Bond Cleavage in Rhodium-Catalyzed C-H Bond Functionalization of Quinoline N-oxides with Alkynes:A Computational Study” Li, Y.; Liu, S.; Qi, Z.; Qi, X.; Li, X.*; Lan, Y.* Chem.-Eur. J. 2015, 21, 10131-10137. (DOI: 10.1002/chem.201500290)

(18) “Dinuclear versus mononuclear pathways in zinc mediated nucleophilic addition: a combined experimental and DFT study” Qi, X.; Li, Y.; Zhang, G.; Li, Y.; Lei, A.*; Liu, C.*; Lan, Y.* Dalton Trans. 2015, 44, 11165-11171. (DOI: 10.1039/c5dt01366f)

(17) “Tuning radical reactivity using iodine in oxidative C(sp3)–H/C(sp)–H cross-coupling: an easy way toward the synthesis of furans and indolizines” Tang, S.; Liu, K.; Long, Y.; Qi, X.; Lan, Y.*; Lei, A.* Chem. Commun. 2015, 51, 8769-8772. (DOI: 10.1039/c5cc01825k)

(16) “Nickel-Catalyzed Selective Oxidative Radical Cross-Coupling: An Effective Strategy for Inert Csp3−H Functionalization” Liu, D.; Li, Y.; Qi, X.; Liu, C.; Lan, Y.*; Lei, A.* Org. Lett. 2015, 17, 998-1001. (DOI: 10.1021/acs.orglett.5b00104)

(15) “Bimetallic zinc complex–active species in coupling of terminal alkynes with aldehydes via nucleophilic addition/Oppenauer oxidation” Yuan, J.; Wang, J.; Zhang, G.; Liu, C.; Qi, X.; Lan, Y.*; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lei, A.* Chem. Commun. 2015, 51, 576-579. (DOI: 10.1039/c4cc08152h)

(14) “Revealing the halide effect on the kinetics of the aerobic oxidation of Cu(I) to Cu(II) ” Deng, Y.; Zhang, G.; Qi, X.; Liu, C.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lan, Y.*; Lei, A.* Chem. Commun. 2015, 51, 318-321. (DOI: 10.1039/c4cc05720a)

(13) “Transition-Metal-Free Formal Decarboxylative Coupling of a-Oxocarboxylates with a-Bromoketones under Neutral Conditions: A Simple Access to 1,3-Diketones” He, Z.; Qi, X.; Li, S.; Zhao, Y.; Gao, G.*; Lan, Y.*; Wu, Y.; Lan, J.; You, J.* Angew. Chem. Int. Ed. 2015, 54, 855-859. (DOI: 10.1002/anie.201409361)

(12) “Rhodium-Catalyzed C−H Activation of Phenacyl Ammonium Salts Assisted by an Oxidizing C−N Bond: A Combination of Experimental and Theoretical Studies” Yu, S.; Liu, S.; Lan, Y.*; Wan, B.*; Li, X.* J. Am. Chem. Soc. 2015, 137, 1623-1631. (DOI: 10.1021/ja511796h)

(11) “Transition-Metal-Assisted Radical/Radical Cross-Coupling: A New Strategy to the Oxidative C(sp3)−H/N−H Cross-Coupling” Zhou, L.; Tang, S.; Qi, X.; Lin, C.; Liu, K.; Liu, C.; Lan, Y.*; Lei, A.* Org. Lett. 2014, 16, 3404-3407. (DOI: 10.1021/ol501485f)

(10) “Carbon-Centered Radical Addition to O=C of Amides or Esters as a Route to CO Bond Formations” Liu, D.; Tang, S.; Yi, H.; Liu, C.; Qi, X.; Lan, Y.*; Lei, A.* Chem.-Eur. J. 2014, 20, 15605-15610. (DOI: 10.1002/chem.201404607)

(9) “Chemoselective Carbophilic Addition of a-Diazoesters through Ligand-Controlled Gold Catalysis” Xi, Y.; Su, Y.; Yu, Z.; Dong, B.; McClain, E. J.; Lan, Y.*; Shi, X.* Angew. Chem. Int. Ed. 2014, 53, 9817-9821. (DOI: 10.1002/anie.201404946)

(8) “Visible-Light-Mediated Decarboxylation/Oxidative Amidation of a-Keto Acids with Amines under Mild Reaction Conditions Using O2” Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R.; Qi, X.; Lan, Y.*; Lei, A.* Angew. Chem. Int. Ed. 2014, 53, 502-506. (DOI: 10.1002/anie.201308614)

(7) “Cu(II)−Cu(I) Synergistic Cooperation to Lead the Alkyne C−H Activation” Bai, R.; Zhang, G.; Yi, H.; Huang, Z.; Qi, X.; Liu, C.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Lan, Y.*; Lei, A.* J. Am. Chem. Soc. 2014, 136, 16760-16763. (DOI: 10.1021/ja5097489)

(6) “Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition” Long, R.; Huang, J.; Shao, W.; Liu, S.; Lan, Y.*; Gong, J.*; Yang, Z.* Nat. Commun. 2014, 5, 5707. (DOI: 10.1038/ncomms6707)

(5) “Theoretical study of the electron-donating effects of thiourea ligands in catalysis” Liu, S.; Lei, Y.; Yang, Z.*; Lan, Y.* J. Mol. Struct. 2014, 1074, 527-533. (DOI:10.1016/j.molstruc.2014.06.034)

(4) “Hexahapto-chromium complexes of graphene: a theoretical study” Liu, S.; Lei, Y.; Li, Y.; Zhang, T.; Wang, H.; Lan, Y.* RSC Adv. 2014, 4, 28640. (DOI: 10.1039/c4ra03702b)

(3) “What Controls Stereoselectivity and Reactivity in the Synthesis of a trans-Decalin with a Quaternary Chiral Center via the Intramolecular Pauson−Khand Reaction: A Theoretical Study” Liu, S.; Shen, H.; Yu, Z.; Shi, L.; Yang, Z.*; Lan, Y.* Organometallics 2014, 33, 6282-6285. (DOI: 10.1021/om500840q )

(2) “Reactivity for the Diels−Alder Reaction of Cumulenes: A Distortion-Interaction Analysis along the Reaction Pathway” Liu, S.; Lei, Y.; Qi, X.; Lan, Y.* J. Phys. Chem. A 2014, 118, 2638-2645. (DOI: 10.1021/jp411914u)

(1) “Mechanism of Rhodium-Catalyzed Carbon−Silicon Bond Cleavage for the Synthesis of Benzosilole Derivatives: A Computational Study” Yu, Z.; Lan, Y.* J. Org. Chem. 2013, 78, 11501-11507. (DOI: 10.1021/jo402070f)

(二)第一作者论文

(8) “Why Nature Eschews the Concerted [2+2+2] Cycloaddition of a Nonconjugated Cyanodiyne. Computational Study of a Pyridine Synthesis Involving an Ene−Diels−Alder−Bimolecular Hydrogen- Transfer Mechanism” Lan, Y.; Danheiser, R. L.*; Houk, K. N.* J. Org. Chem. 2012, 77, 1533-1538. (DOI: 10.1021/jo202424n)

(7) “Theoretical study of Pd(0)-catalyzed carbohalogenation of alkenes: mechanism and origins of reactivities and selectivities in alkyl halide reductive elimination from Pd(II) species” Lan, Y.; Liu, P.; Newman, S. G.; Lautens, M.*; Houk, K. N.* Chem. Sci. 2012, 3, 1987. (DOI: 10.1039/c2sc20103h)

(6) “Computational Methods To Calculate Accurate Activation and Reaction Energies of 1,3-Dipolar Cycloadditions of 24 1,3-Dipoles” Lan, Y.; Zou, L.; Cao, Y.; Houk, K. N.* J. Phys. Chem. A 2011, 115, 13906-13920. (DOI: 10.1021/jp207563h)

(5) “Mechanism of the Palladium-Catalyzed Addition of Arylboronic Acids to Enones: A Computational Study” Lan, Y.; Houk, K. N.* J. Org. Chem. 2011, 76, 4905-4909. (DOI: 10.1021/jo2002903)

(4) “Extraordinary Difference in Reactivity of Ozone (OOO) and Sulfur Dioxide (OSO): A Theoretical Study” Lan, Y.; Wheeler, S. E.; Houk, K. N.* J. Chem. Theory Comput. 2011, 7, 2104-2111. (DOI: 10.1021/jo902163v)

(3) “A Theoretical Investigation on the Mechanism of a Palladium-Mediated Formal 6π Electrocyclic Synthesis of 9,10-Dihydrophenanthrenes” Lan, Y.; Wang, C.; Sowa, J. R., Jr.; Wu, Y. D.* J. Org. Chem. 2010, 75, 951-954. (DOI: 10.1021/jo902163v)

(2) “Mechanism and Stereoselectivity of the Stepwise 1,3-Dipolar Cycloadditions between a Thiocarbonyl Ylide and Electron-Deficient Dipolarophiles: A Computational Investigation” Lan, Y.; Houk, K. N.* J. Am. Chem. Soc. 2010, 132, 17921-17927. (DOI: 10.1021/ja108432b)

(1) “On the Mechanism of the Palladium Catalyzed Intramolecular Pauson-Khand-Type Reaction” Lan, Y.; Deng, L.; Liu, J.; Wang, C.; Wiest, O.; Yang, Z.*; Wu, Y. D.* J. Org. Chem. 2009, 74, 5049-5058. (DOI: 10.1021/jo900919v)

(三)共同作者论文

(22) “Oxidation-induced C–H amination leads to a new avenue to build C–N bonds” Yi, H.; Tang, Z.; Bian, C.; Chen, H.; Qi, X.; Yue, X.; Lan, Y.; Lee, J.-F.; Lei, A.* Chem. Commun. 2017, 53, 8984-8987. (DOI: 10.1039/c7cc04955b)

(21) “Coordination strategy-induced selective C–H amination of 8-aminoquinolines” Yi, H.; Chen, H.; Bian, C.; Tang, Z.; Singh, A. K.; Qi, X.; Yue, X.; Lan, Y.; Lee, J.-F.; Lei, A.* Chem. Commun. 2017, 53, 6736-6739. (DOI: 10.1039/c7cc02601c)

(20) “Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates” Yi, H.; Yang, D.; Xin, J.; Qi, X.; Lan, Y.; Deng, Y.*; Pao, C.-W.; Lee, J.-F.; Lei, A.* Nat. Commun. 2017, 8, 14794. (DOI: 10.1038/ncomms14794)

(19) “Highly enantioselective nitro-Mannich reaction of ketimines under phase-transfer catalysis” Wang, B.; Xu, T.; Zhu, L.; Lan, Y.; Wang, J.; Lu, N.; Wei, Z.; Lin, Y.*; Duan, H. Org. Chem. Front. 2017, 4, 1266-1271. (DOI: 10.1039/C7QO00124J)

(18) “Aromatic C–H bond cleavage by using a Cu(I) ate-complex” Zhang, G.; Yi, H.; Xin, J.; Deng, Y.; Bai, R.; Huang, Z.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Qi, X.; Lan, Y.; Lei, A.* Org. Chem. Front. 2016, 3, 975-978. (DOI: 10.1039/c6qo00201c)

(17) “Catalytic N-radical cascade reaction of hydrazones by oxidative deprotonation electron transfer and TEMPO mediation” Hu, X.-Q.; Qi, X.; Chen, J.-R.*; Zhao, Q.-Q.; Wei, Q.; Lan, Y.; Xiao, W.-J. Nat. Commun. 2016, 7, 11188. (DOI: 10.1038/ncomms11188)

(16) “Homolytic cleavage of the O–Cu(II) bond: XAFS and EPR spectroscopy evidence for one electron reduction of Cu(II) to Cu(I)” Yi, H.; Zhang, G.; Xin, J.; Deng, Y.; Miller, J. T.; Kropf, A. J.; Bunel, E. E.; Qi, X.; Lan, Y.; Lee, J.-F.; Lei, A.* Chem. Commun. 2016, 52, 6914-6917. (DOI: 10.1039/c6cc01413e)

(15) “Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling” Zhou, L.; Yi, H.; Zhu, L.; Qi, X.; Jiang, H.; Liu, C.; Feng, Y.; Lan, Y.; Lei, A.* Sci. Rep. 2015, 5, 15934. (DOI: 10.1038/srep15934)

(14) “Carboxylate-Assisted C(sp3)−H Activation in Olefin Metathesis-Relevant Ruthenium Complexes” Cannon, J. S.; Zou, L.; Liu, P.; Lan, Y.; O'Leary, D. J.; Houk, K. N.*; Grubbs, R. H.* J. Am. Chem. Soc. 2014, 136, 6733-6743. (DOI: 10.1021/ja5021958)

(13) “Mechanism and Enantioselectivity in Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to βSubstituted Cyclic Enones: Insights from Computation and Experiment” Holder, J. C.; Zou, L.; Marziale, A. N.; Liu, P.; Lan, Y.; Gatti, M.; Kikushima, K.; Houk, K. N.*; Stoltz, B. M.* J. Am. Chem. Soc. 2013, 135, 14996-15007. (DOI: 10.1021/ja401713g)

(12) “Understanding Reactivity and Stereoselectivity in Palladium-Catalyzed Diastereoselective sp3 C−H Bond Activation: Intermediate Characterization and Computational Studies” Giri, R.; Lan, Y.; Liu, P.; Houk, K. N.*; Yu, J. Q.* J. Am. Chem. Soc. 2012, 134, 14118-14126. (DOI: 10.1021/ja304643e)

(11) “Decomposition Pathways of Z-Selective Ruthenium Metathesis Catalysts” Herbert, M. B.; Lan, Y.; Keitz, B. K.; Liu, P.; Endo, K.; Day, M. W.; Houk, K. N.*; Grubbs, R. H.* J. Am. Chem. Soc. 2012, 134, 7861-7866. (DOI: 10.1021/ja301108m)

(10) “A novel self-promoted Morita-Baylis-Hillman-like dimerization” Li, Q.; Wongkhan, K.; Luo, X.; Batsanov, A. S.; Howard, J. A. K.; Lan, Y.; Wu, Y.*; Marder, T. B.*; Lei, A.* Chin. Sci. Bull. 2010, 55, 2794-2798. (DOI: 10.1007/s11434-010-3270-9)

(9) “Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides” Hu, Y.; Liu, J.; Lu, Z.; Luo, X.; Zhang, H.; Lan, Y.; Lei, A.* J. Am. Chem. Soc. 2010, 132, 3153-3158. (DOI: 10.1021/ja909962f)

(8) “Revealing a Second Transmetalation Step in the Negishi Coupling and Its Competition with Reductive Elimination: Improvement in the Interpretation of the Mechanism of Biaryl Syntheses” Liu, Q.; Lan, Y.; Liu, J.; Li, G.; Wu, Y. D.*; Lei, A.* J. Am. Chem. Soc. 2009, 131, 10201-10210. (DOI: 10.1021/ja903277d)

(7) “Revelation of the Difference between Arylzinc Reagents Prepared from Aryl Grignard and Aryllithium Reagents Respectively: Kinetic and Structural Features” Jin, L.; Liu, C.; Liu, J.; Hu, F.; Lan, Y.; Batsanov, A. S.; Howard, J. A.; Marder, T. B.*; Lei, A.* J. Am. Chem. Soc. 2009, 131, 16656-16657. (DOI: 10.1021/ja908198d)

(6) “Stereoselective Construction of an Unprecedented 7-8 Fused Ring System in Micrandilactone A by [3,3]-Sigmatropic Rearrangement” Zhang, Y.-D.; Ren, W.-W.; Lan, Y.; Xiao, Q.; Wang, K.; Xu, J.; Chen, J.-H.*; Yang, Z.* Org. Lett. 2008, 10, 665-668. (DOI: 10.1021/ol703126q)

(5) “Effect of Lithium Chloride on Tuning the Reactivity of Pauson–Khand Reactions Catalyzed by Palladium–Tetramethylthiourea” Yang, Z.*; Lei, A.*; Chen, J.-H.*; Deng, L.-J.; Liu, J.; Huang, J.-Q.; Hu, Y.; Chen, M.; Lan, Y. Synthesis 2007, 2007, 2565-2570. (DOI: 10.1055/s-2007-983796)

(4) “Synthesis of Thiourea-Oxazolines, a New Class of Chiral S,N-Heterobidentate Ligands: Application in Pd-Catalyzed Asymmetric Bis(methoxycarbonylation) of Terminal Olefins” Liang, B.; Liu, J.; Gao, Y.-X.; Wongkhan, K.; Shu, D.-X.; Lan, Y.; Li, A.; Batsanov, A. S.; Howard, J. A. H.; Marder, T. B.*; Chen, J.-H.*; Yang, Z.* Organometallics 2007, 26, 4756-4762. (DOI: 10.1021/om700311x)

(3) “Convenient and Efficient Synthesis of 1,1-Bis-(4-alkylthiophenyl)-1-alkenes via Tandem Friedel–Crafts Acylation and Alkylation of Sulfides and Acyl Chlorides” Xu, J.*; Xia, J.; Lan, Y. Synth. Commun. 2005, 35, 2347-2353. (DOI: 10.1080/00397910500187373)

(2) “Mildly and Highly Selective Reductive Deoxygenation of para-Di- and Monoalkylaminophenyl Ketones by Borane” Wei, T.; Lan, Y.; Xu, J.* Heteroat. Chem. 2005, 16, 2-5. (DOI: 10.1002/hc.20062)

(1) “Chiral Oxazaborolidine-catalyzed Asymmetric Borane Reduction of Alkyl 4-Dialkylaminophenyl Ketones” Xu, J.-X.*; Lan, Y.; Wei, T.-Z.; Zhang, Q.-H. Chin. J. Chem. 2005, 23, 1457-1461. (DOI: 10.1002/cjoc.200591457)

 

 

 

 

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